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Cerebral open flow microperfusion (cOFM) an innovative interface to brain tissue

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Contributing authors of JOANNEUM RESEARCH:
DI Dr. Thomas Birngruber; Priv.-Doz. DI Dr. Frank Sinner
Authors
Birngruber, Thomas; Sinner, Frank
Abstract:
Cerebral open flow microperfusion (cOFM) is a new in-vivo technique for continuous sampling of the interstitial fluid in brain tissue. cOFM can be used to monitor substance transport across the blood-brain barrier (pharmacokinetics) and to investigate metabolic changes in brain tissue after drug application (pharmacodynamics). The possibility of long-term implantation into the brain makes cOFM an outstanding tool in the development of brain relevant pharmaceutics.
Title:
Cerebral open flow microperfusion (cOFM) an innovative interface to brain tissue
Seiten:
19–25
Publikationsdatum
2016-06

Publikationsreihe

Nummer
20
ISSN
17406749
Proceedings
Drug Discovery Today: Technologies
More files and links
https://linkinghub.elsevier.com/retrieve/pii/S1740674916300166
DOI-Url:
https://www.doi.org/ 10.1016/j.ddtec.2016.07.003
Jahr/Monat:
2016
Bibtex Download

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