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DI Dr. Manfred Bodenlenz

Phone number

+43 316 876-4115

E-mail

Manfred.Bodenlenz@joanneum.at

Adress

Neue Stiftingtalstraße 2, 8010, Graz
+43 316 876-4000
health@joanneum.at

Publications

Health
2024

Comparative Study of Dermal Pharmacokinetics Between Topical Drugs Using Open Flow Microperfusion in a Pig Model

Authors Bodenlenz M, Yeaho T, Berstein G, Mathew S, Shah J, Banfield C, Hollingshead B, Steyn S, Osgood S, Beaumont K, Kainz S, Holecek C, Trausinger G, Raml R, Birngruber T
Comparative Study of Dermal Pharmacokinetics Between Topical Drugs Using Open Flow Microperfusion in a Pig Model
Health
2021

Characterizing Cutaneous Drug Delivery Using Open-Flow Microperfusion and Mass Spectrometry Imaging

Authors Handler, Anne Mette; Eirefelt, Stefan; Lambert, Maja; Johansson, Fredrik; Hollesen Schefe, Line; Østergaard Knudsen, Nina; Bodenlenz, Manfred; Birngruber, Thomas; Sinner, Frank; Huss Erikson, André; Pommergaard Pedersen, Gitte; Janfelt, Christian; Troensegaard Nielsen, Kim
Characterizing Cutaneous Drug Delivery Using Open-Flow Microperfusion and Mass Spectrometry Imaging
Health
2020

Variability of Skin Pharmacokinetic Data: Insights from a Topical Bioequivalence Study Using Dermal Open Flow Microperfusion

Authors Bodenlenz, Manfred; Augustin, Thomas; Birngruber, Thomas; Tiffner, Katrin Irene; Boulgaropoulos, Beate; Schwingenschuh, Simon; Raney, Sam G.; Rantou, Elena; Sinner, Frank
Variability of Skin Pharmacokinetic Data: Insights from a Topical Bioequivalence Study Using Dermal Open Flow Microperfusion
Health
2019

LC/MS/MS analyses of open-flow microperfusion samples quantify eicosanoids in a rat model of skin inflammation

Authors Pipper, Cornelia; Bordag, Natalie; Reiter, Bernadette; Economides, Kyriakos; Florian, Peter; Birngruber, Thomas; Sinner, Frank; Bodenlenz, Manfred; Eberl, Anita
LC/MS/MS analyses of open-flow microperfusion samples quantify eicosanoids in a rat model of skin inflammation
Health
2018

Quantification of acyclovir in dermal interstitial fluid and human serum by ultra-high-performance liquid-high-resolution tandem mass spectrometry for topical bioequivalence evaluation

Authors Schimek, Denise; Raml, Reingard; Francesconi, Kevin A.; Bodenlenz, Manfred; Sinner, Frank
Quantification of acyclovir in dermal interstitial fluid and human serum by ultra-high-performance liquid-high-resolution tandem mass spectrometry for topical bioequivalence evaluation
Health
2017

Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence

Authors Bodenlenz, Manfred; Tiffner, Katrin Irene; Raml, Reingard; Augustin, Thomas; Dragatin, Christian; Birngruber, Thomas; Schimek, Denise; Schwagerle, Gerd; Pieber, Thomas R.; Raney, Sam G.; Kanfer, Isadore; Sinner, Frank
Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence
Health
2017

β-Defensin 2 is a responsive biomarker of IL-17A–driven skin pathology in patients with psoriasis

Authors Kolbinger, Frank; Loesche, Christian; Valentin, Marie-Anne; Jiang, Xiaoyu; Cheng, Yi; Jarvis, Philip; Peters, Thomas; Calonder, Claudio; Bruin, Gerard; Polus, Florine; Aigner, B; Lee, David M.; Bodenlenz, Manfred; Sinner, Frank; Pieber, Thomas R; Patel, Dhavalkumar D.
β-Defensin 2 is a responsive biomarker of IL-17A–driven skin pathology in patients with psoriasis
Health
2016

Secukinumab distributes into dermal interstitial fluid of psoriasis patients as demonstrated by open flow microperfusion.

Authors Dragatin, Christian; Polus, Florine; Bodenlenz, Manfred; Calonder, Claudio; Aigner, Birgit; Tiffner, Katrin Irene; Mader, Julia Katharina; Ratzer, Maria; Woessner, Ralph; Pieber, Thomas R; Cheng, Yi; Loesche, Christian; Sinner, Frank M.; Bruin, Gerard
Secukinumab distributes into dermal interstitial fluid of psoriasis patients as demonstrated by open flow microperfusion.
Health
2016

Kinetics of Clobetasol-17-Propionate in Psoriatic Lesional and Non-Lesional Skin Assessed by Dermal Open Flow Microperfusion with Time and Space Resolution

Authors Bodenlenz, Manfred; Dragatin, Christian; Liebenberger, Lisa; Tschapeller, Bernd; Boulgaropoulos, Beate; Augustin, Thomas; Raml, Reingard; Gatschelhofer, Christina; Wagner, Nathalie; Benkali, Khaled; Rony, Francois; Pieber, Thomas; Sinner, Frank
Kinetics of Clobetasol-17-Propionate in Psoriatic Lesional and Non-Lesional Skin Assessed by Dermal Open Flow Microperfusion with Time and Space Resolution
Health
2015

Bioavailability of insulin detemir and human insulin at the level of peripheral interstitial fluid in humans, assessed by open-flow microperfusion.

Authors Bodenlenz, Manfred; Ellmerer, M; Schaupp, L; Jacobsen, L V; Plank, J; Brunner, G. A.; Wutte, A; Aigner, B; Mautner, Selma Isabella; Pieber, Thomas R
Bioavailability of insulin detemir and human insulin at the level of peripheral interstitial fluid in humans, assessed by open-flow microperfusion.
Health
2013

Clinical applicability of dOFM devices for dermal sampling.

Authors Bodenlenz, Manfred; Aigner, B; Dragatin, C; Liebenberger, L; Zahiragic, S; Höfferer, C; Birngruber, Thomas; Priedl, J; Feichtner, F; Schaupp, L; Korsatko, S; Ratzer, M; Magnes, Christoph; Pieber, Thomas R; Sinner, F
Clinical applicability of dOFM devices for dermal sampling.
Health
2013

Periodic Extraction of Interstitial Fluid from the Site of Subcutaneous Insulin Infusion for the Measurement of Glucose: A Novel Single-Port Technique for the Treatment of Type 1 Diabetes Patients

Authors Regittnig, Werner; Lindpointner, Stefan; Korsatko, Stefan; Tutkur, Dina; Bodenlenz, Manfred; Pieber, Thomas R.
Periodic Extraction of Interstitial Fluid from the Site of Subcutaneous Insulin Infusion for the Measurement of Glucose: A Novel Single-Port Technique for the Treatment of Type 1 Diabetes Patients
Health
2012

Dermal PK/PD of a lipophilic topical drug in psoriatic patients by continuous intradermal membrane-free sampling

Authors Bodenlenz, Manfred; Höfferer, Christian; Magnes, Christoph; Schaller-Ammann, Roland; Schaupp, Lukas; Feichtner, Franz; Ratzer, Maria; Pickl, Karin; Sinner, Frank; Wutte, Andrea; Korsatko, Stefan; Köhler, Gerd; Legat, Franz J.; Benfeldt, Eva M.; Wright, Andrew M.; Neddermann, Daniel; Jung, Thomas; Pieber, Thomas R
Dermal PK/PD of a lipophilic topical drug in psoriatic patients by continuous intradermal membrane-free sampling
Health
2012

Open Flow Microperfusion: An Alternative Method to Microdialysis?

Authors Pieber, Thomas R; Birngruber, Thomas; Bodenlenz, Manfred; Höfferer, Christian; Mautner, S. I.; Tiffner, Katrin Irene; Sinner, Frank M.
Open Flow Microperfusion: An Alternative Method to Microdialysis?
Health
2012

Comparison of Open-Flow Microperfusion and Microdialysis Methodologies When Sampling Topically Applied Fentanyl and Benzoic Acid in Human Dermis Ex Vivo

Authors Holmgaard, Rikke; Benfeldt, E; Nielsen, J B; Gatschelhofer, C; Sorensen, J a; Höfferer, C; Bodenlenz, Manfred; Pieber, Thomas R; Sinner, F.
Comparison of Open-Flow Microperfusion and Microdialysis Methodologies When Sampling Topically Applied Fentanyl and Benzoic Acid in Human Dermis Ex Vivo
Health
2010

Interleukin-6 produced in subcutaneous adipose tissue is linked to blood pressure control in septic patients

Authors Ikeoka, Dimas; Pachler, Christoph; Korsatko, Stefan; Mader, Julia Katharina; Weinhandl, Heinz; Bodenlenz, Manfred; Plank, Johannes; Smolle, Karl-Heinz; Ellmerer, Martin; Pieber, Thomas R
Interleukin-6 produced in subcutaneous adipose tissue is linked to blood pressure control in septic patients
Health
2010

Subcutaneous adipose tissue exerts proinflammatory cytokines after minimal trauma in humans

Authors Pachler, Christoph; Ikeoka, Dimas; Plank, Johannes; Weinhandl, Heinz; Mader, Julia K; Bodenlenz, Manfred; Regittnig, Werner; Mangge, Harald; Pieber, Thomas R; Ellmerer, Martin; Suppan, Maria
Subcutaneous adipose tissue exerts proinflammatory cytokines after minimal trauma in humans
Health
2009

A novel automated discontinuous venous blood monitoring system for ex vivo glucose determination in humans

Authors Schaller, R; Feichtner, F; Köhler, H; Bodenlenz, Manfred; Plank, J; Wutte, A; Mader, J.K.; Ellmerer, M; Hellmich, R; Wedig, H; Hainisch, R; Pieber, T.R.; Schaupp, L
A novel automated discontinuous venous blood monitoring system for ex vivo glucose determination in humans
Health
2008

Insulin glulisine, insulin lispro and regular human insulin show comparable end-organ metabolic effects: an exploratory study

Authors Horvath, K; Bock, G; Regittnig, W; Bodenlenz, Manfred; Wutte, A; Plank, J; Magnes, Christoph; Sinner, F.; Fürst-Recktenwald, S.; Theobald, K; Pieber, Thomas R
Insulin glulisine, insulin lispro and regular human insulin show comparable end-organ metabolic effects: an exploratory study
Health
2007

Proportional Dose-Response Relationship and Lower Within-Patient Variability of Insulin Detemir and NPH Insulin in Subjects With Type 1 Diabetes Mellitus

Authors Wutte, A; Plank, J; Bodenlenz, Manfred; Magnes, Christoph; Regittnig, W; Sinner, F.; Rønn, B.; Zdravkovic, M; Pieber, T.
Proportional Dose-Response Relationship and Lower Within-Patient Variability of Insulin Detemir and NPH Insulin in Subjects With Type 1 Diabetes Mellitus
Health
2007

Rapid online-SPE-MS/MS method for ketoprofen determination in dermal interstitial fluid samples from rats obtained by microdialysis or open-flow microperfusion

Authors Pickl, Karin E.; Magnes, Christoph; Bodenlenz, Manfred; Pieber, Thomas R.; Sinner, Frank M.
Rapid online-SPE-MS/MS method for ketoprofen determination in dermal interstitial fluid samples from rats obtained by microdialysis or open-flow microperfusion
Health
2007

Bedside monitoring of subcutaneous interstitial glucose in healthy individuals using microdialysis and infrared spectrometry

Authors Heise, H Michael; Damm, Uwe; Bodenlenz, Manfred; Kondepati, Venkata Radhakrishna; Köhler, Gerd; Ellmerer, Martin
Bedside monitoring of subcutaneous interstitial glucose in healthy individuals using microdialysis and infrared spectrometry
Health
2006

On-line adaptive algorithm with glucose prediction capacity for subcutaneous closed loop control of glucose: evaluation under fasting conditions in patients with Type 1 diabetes

Authors Schaller, H C; Schaupp, L; Bodenlenz, Manfred; Wilinska, M E; Chassin, L J; Wach, P; Vering, T; Hovorka, R; Pieber, Thomas R
On-line adaptive algorithm with glucose prediction capacity for subcutaneous closed loop control of glucose: evaluation under fasting conditions in patients with Type 1 diabetes
Health
2005

A Double-Blind, Randomized, Dose-Response Study Investigating the Pharmacodynamic and Pharmacokinetic Properties of the Long-Acting Insulin Analog Detemir

Authors Plank, Johannes; Bodenlenz, Manfred; Sinner, Frank; Magnes, Christoph; Görzer, Evelyn; Regittnig, Werner; Endahl, Lars A.; Draeger, Eberhard; Zdravkovic, Milan; Pieber, Thomas R
A Double-Blind, Randomized, Dose-Response Study Investigating the Pharmacodynamic and Pharmacokinetic Properties of the Long-Acting Insulin Analog Detemir
Health
2005

Measurement of interstitial insulin in human adipose and muscle tissue under moderate hyperinsulinemia by means of direct interstitial access

Authors Bodenlenz, Manfred; Schaupp, Lukas A; Druml, Tatjana; Sommer, Romana; Wutte, Andrea; Schaller, Helga C; Sinner, Frank; Wach, Paul; Pieber, Thomas R
Measurement of interstitial insulin in human adipose and muscle tissue under moderate hyperinsulinemia by means of direct interstitial access
Health
2004

Closing the Loop: The Adicol Experience

Authors Hovorka, Roman; Chassin, Ludovic J; Wilinska, Malgorzata E; Canonico, Valentina; Akwi, Joyce Akwe; Federici, Marco Orsini; Massi-Benedetti, Massimo; Hutzli, Ivo; Zaugg, Claudio; Kaufmann, Heiner; Both, Marcel; Vering, Thomas; Schaller, Helga C; Schaupp, Lukas; Bodenlenz, Manfred; Pieber, Thomas R
Closing the Loop: The Adicol Experience
Health
2004

Interstitial glucose kinetics in subjects with type 1 diabetes under physiologic conditions.

Authors Wilinska, M E; Bodenlenz, Manfred; Chassin, L J; Schaller, H C; Schaupp, L A; Pieber, Thomas R; Hovorka, R
Interstitial glucose kinetics in subjects with type 1 diabetes under physiologic conditions.
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JOANNEUM RESEARCH provides innovation and technology services in the field of applied research. As a research company working on behalf of various federal provinces and regions in Austria, our expertise shapes the development of our modern society and economy – sustainably, and always with a focus on people. As a multidisciplinary team working in a flexible set-up that fosters innovation, we always live up to the highest social and scientific standards.

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