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DI Dr. Thomas Birngruber

Role

Stv. Direktor, Forschungsgruppenleiter

Research group

HEALTH:

Biomedizinisches Gewebemonitoring

Phone number

+43 316 876-4114

E-mail

Thomas.Birngruber@joanneum.at

Adress

Neue Stiftingtalstraße 2, 8010, Graz
+43 316 876-4000
health@joanneum.at

Publications

Health
2024

Comparative Study of Dermal Pharmacokinetics Between Topical Drugs Using Open Flow Microperfusion in a Pig Model

Authors Bodenlenz M, Yeaho T, Berstein G, Mathew S, Shah J, Banfield C, Hollingshead B, Steyn S, Osgood S, Beaumont K, Kainz S, Holecek C, Trausinger G, Raml R, Birngruber T
Comparative Study of Dermal Pharmacokinetics Between Topical Drugs Using Open Flow Microperfusion in a Pig Model
Health
2023

Detailed pharmacokinetic characterization of advanced topical acyclovir formulations with IVPT and in vivo Open Flow Microperfusion

Authors Schwagerle, Gerd; Sharp, Matthew J; Parr, Alan; Schimek, Denise; Mautner, Selma I; Birngruber, Thomas
Detailed pharmacokinetic characterization of advanced topical acyclovir formulations with IVPT and in vivo Open Flow Microperfusion
Health
2023

Quantification of the Therapeutic Antibody Ocrelizumab in Mouse Brain Interstitial Fluid Using Cerebral Open Flow Microperfusion and Simultaneous Monitoring of the Blood–Brain Barrier Integrity

Authors Altendorfer-Kroath, Thomas; Hummer, Joanna; Kollmann, Denise; Boulgaropoulos, Beate; Raml, Reingard; Birngruber, Thomas
Quantification of the Therapeutic Antibody Ocrelizumab in Mouse Brain Interstitial Fluid Using Cerebral Open Flow Microperfusion and Simultaneous Monitoring of the Blood–Brain Barrier Integrity
Health
2023

Atraumatic access to human glioblastoma in a xenograft animal model by cerebral open flow microperfusion

Authors Altendorfer-Kroath, Thomas; Asslaber, Martin; Hummer, Joanna; Boulgaropoulos, Beate; Prietl, Barbara; Pieber, Thomas R.; Bernhart, Eva; Birngruber, Thomas
Atraumatic access to human glioblastoma in a xenograft animal model by cerebral open flow microperfusion
Health
2023

Small volume rapid equilibrium dialysis (RED) measures effects of interstitial parameters on the protein-bound fraction of topical drugs

Authors Wiltschko, Laura; Roblegg, Eva; Raml, Reingard; Birngruber, Thomas
Small volume rapid equilibrium dialysis (RED) measures effects of interstitial parameters on the protein-bound fraction of topical drugs
Health
2023

In vivo monitoring of brain pharmacokinetics and pharmacodynamics with cerebral open flow microperfusion

Authors Altendorfer‐Kroath, Thomas; Hummer, Joanna; Birngruber, Thomas
In vivo monitoring of brain pharmacokinetics and pharmacodynamics with cerebral open flow microperfusion
Health
2023

Topical Delivery Systems Effectively Transport Analgesics to Areas of Localized Pain via Direct Diffusion

Authors Birngruber T, Vought K, Schwingenschuh S, Reisenegger P, Maibach H, Lissin D
Topical Delivery Systems Effectively Transport Analgesics to Areas of Localized Pain via Direct Diffusion
Health
2022

Dermal open flow microperfusion for PK-based clinical bioequivalence studies of topical drug products

Authors Birngruber, Thomas; Tiffner, Katrin Irene; Mautner, Selma I; Sinner, Frank M.
Dermal open flow microperfusion for PK-based clinical bioequivalence studies of topical drug products
Health
2022

The Impact of Prolonged Inflammation on Wound Healing

Authors Holzer-Geissler, Judith C. J.; Schwingenschuh, Simon; Zacharias, Martin; Einsiedler, Johanna; Kainz, Sonja; Reisenegger, Peter; Holecek, Christian; Hofmann, Elisabeth; Wolff-Winiski, Barbara; Fahrngruber, Hermann; Birngruber, Thomas; Kamolz, Lars-Peter; Kotzbeck, Petra
The Impact of Prolonged Inflammation on Wound Healing
Health
2022

Advanced Online Monitoring of In Vitro Human 3D Full-Thickness Skin Equivalents

Authors Schaller-Ammann, Roland; Kreß, Sebastian; Feiel, Jürgen; Schwagerle, Gerd; Priedl, Joachim; Birngruber, Thomas; Kasper, Cornelia; Egger, Dominik
Advanced Online Monitoring of In Vitro Human 3D Full-Thickness Skin Equivalents
Health
2022

Optimization of topical formulations using a combination of in vitro methods to quantify the transdermal passive diffusion of drugs

Authors Hummer, Joanna; Birngruber, Thomas; Sinner, Frank; Page, Leanne; Toner, Frank; Roper, Clive S.; Moore, David J.; Baker, Mark B.; Boncheva Bettex, Mila
Optimization of topical formulations using a combination of in vitro methods to quantify the transdermal passive diffusion of drugs
Health
2022

ImmUniverse Consortium: Multi-omics integrative approach in personalized medicine for immune-mediated inflammatory diseases

Authors Vetrano, Stefania; Bouma, Gerben; Benschop, Robert J.; Birngruber, Thomas; Costanzo, Antonio; D'Haens, G. R. A. M.; Frasca, Loredana; Hillenbrand, Rainer; Iversen, Lars; Johansen, Claus; Kaser, Arthur; Koenen, Hans J. P. M.; Noehammer, Christa; Peyrin-Biroulet, Laurent; Raes, Jeroen; Ricotti, Leonardo; Rosenstiel, Philip; Satagopam, Venkata P.; Schreiber, Stefan; Vermeire, Severine; Wollenberg, Andreas; Weidinger, Stephan; Ziemek, Daniel; Danese, Silvio
ImmUniverse Consortium: Multi-omics integrative approach in personalized medicine for immune-mediated inflammatory diseases
Coremed, Health
2022

The Impact of Prolonged Inflammation on Wound Healing

Authors Holzer-Geissler JCJ; Schwingenschuh S; Zacharias M; Einsiedler J ; Kainz S; Reisenegger P; Holecek C; Hofmann E ; Wolff-Winiski B; Fahrngruber H; Birngruber T; Kamolz LP ; Kotzbeck P
The Impact of Prolonged Inflammation on Wound Healing
Coremed +
2021

A novel human ex vivo skin model to study early local responses to burn injuries

Authors Hofmann, Elisabeth; Fink, Julia; Eberl, Anita; Prugger, Eva-Maria; Kolb, Dagmar; Luze, Hanna; Schwingenschuh, Simon; Birngruber, Thomas; Magnes, Christoph; Mautner, Selma I; Kamolz, Lars-Peter; Kotzbeck, Petra
A novel human ex vivo skin model to study early local responses to burn injuries
Health
2021

miRNAs as Regulators of the Early Local Response to Burn Injuries

Authors Foessl, Ines; Haudum, Christoph Walter; Vidakovic, Ivan; Prassl, Ruth; Franz, Joakim; Mautner, Selma I.; Kainz, Sonja; Hofmann, Elisabeth; Obermayer-Pietsch, Barbara; Birngruber, Thomas; Kotzbeck, Petra
miRNAs as Regulators of the Early Local Response to Burn Injuries
Health
2021

Dermal sampling techniques with focus on dermal Open Flow Microperfusion

Authors Birngruber, Thomas; Boulgaropoulos, Beate; Sinner, Frank
Dermal sampling techniques with focus on dermal Open Flow Microperfusion
Health
2021

Characterizing Cutaneous Drug Delivery Using Open-Flow Microperfusion and Mass Spectrometry Imaging

Authors Handler, Anne Mette; Eirefelt, Stefan; Lambert, Maja; Johansson, Fredrik; Hollesen Schefe, Line; Østergaard Knudsen, Nina; Bodenlenz, Manfred; Birngruber, Thomas; Sinner, Frank; Huss Erikson, André; Pommergaard Pedersen, Gitte; Janfelt, Christian; Troensegaard Nielsen, Kim
Characterizing Cutaneous Drug Delivery Using Open-Flow Microperfusion and Mass Spectrometry Imaging
Coremed, Health
2021

miRNAs as Regulators of the Early Local Response to Burn Injuries.

Authors Foessl I; Haudum CW; Vidakovic I; Prassl R; Franz J; Mautner SI ; Kainz S ; Hofmann E ; Obermayer-Pietsch B; Birngruber T ; Kotzbeck P
miRNAs as Regulators of the Early Local Response to Burn Injuries.
Health
2020

Delivery of antiseptic solutions by a bacterial cellulose wound dressing: Uptake, release and antibacterial efficacy of octenidine and povidone-iodine

Authors Bernardelli de Mattos, Ives; Nischwitz, Sebastian P.; Tuca, Alexandru-Cristian; Groeber-Becker, Florian; Funk, Martin; Birngruber, Thomas; Mautner, Selma I.; Kamolz, Lars-Peter; Holzer, Judith C.J.
Delivery of antiseptic solutions by a bacterial cellulose wound dressing: Uptake, release and antibacterial efficacy of octenidine and povidone-iodine
Health
2020

Variability of Skin Pharmacokinetic Data: Insights from a Topical Bioequivalence Study Using Dermal Open Flow Microperfusion

Authors Bodenlenz, Manfred; Augustin, Thomas; Birngruber, Thomas; Tiffner, Katrin Irene; Boulgaropoulos, Beate; Schwingenschuh, Simon; Raney, Sam G.; Rantou, Elena; Sinner, Frank
Variability of Skin Pharmacokinetic Data: Insights from a Topical Bioequivalence Study Using Dermal Open Flow Microperfusion
Coremed +
2020

A novel human ex-vivo burn model and the local cooling effect of a bacterial nanocellulose-based wound dressing

Authors Holzer, Judith C.J.; Tiffner, Katrin Irene; Kainz, Sonja; Reisenegger, Peter; Bernardelli de Mattos, Ives; Funk, Martin; Lemarchand, Thomas; Laaff, Helmut; Bal, Ayse; Birngruber, Thomas; Kotzbeck, Petra; Kamolz, Lars-Peter
A novel human ex-vivo burn model and the local cooling effect of a bacterial nanocellulose-based wound dressing
Health
2020

OFM recirculation and OFM suction: Advanced in-vivo open flow microperfusion methods for direct and absolute quantification of albumin in interstitial fluid

Authors Hummer, Joanna; Schwingenschuh, Simon; Raml, Reingard; Boulgaropoulos, Beate; Schwagerle, Gerd; Augustin, Thomas; Sinner, Frank; Birngruber, Thomas
OFM recirculation and OFM suction: Advanced in-vivo open flow microperfusion methods for direct and absolute quantification of albumin in interstitial fluid
Health and care
2020

Choice and characterization of preclinical models — Towards understanding wound healing

Authors Hofmann, Elisabeth; Nischwitz, Sebastian P.; Holzer, Judith C.J.; Kotzbeck, Petra; Birngruber, Thomas; Kamolz, Lars-Peter
Choice and characterization of preclinical models — Towards understanding wound healing
Health
2020

Evaluating Dermal Pharmacokinetics and Pharmacodymanic Effect of Soft Topical PDE4 Inhibitors: Open Flow Microperfusion and Skin Biopsies

Authors Eirefelt, Stefan; Hummer, Joanna; Basse, Line Hollesen; Bertelsen, Malene; Johansson, Fredrik; Birngruber, Thomas; Sinner, Frank; Larsen, Jens; Nielsen, Simon Feldbæk; Lambert, Maja
Evaluating Dermal Pharmacokinetics and Pharmacodymanic Effect of Soft Topical PDE4 Inhibitors: Open Flow Microperfusion and Skin Biopsies
Coremed, Health
2020

Delivery of antiseptic solutions by a bacterial cellulose wound dressing: Uptake, release and antibacterial efficacy of octenidine and povidone-iodine

Authors Ives Bernardelli de Mattos; Sebastian P Nischwitz ; Alexandru-Cristian Tuca; Florian Groeber-Becker; Martin Funk; Thomas Birngruber ; Selma Mautner ; Lars-Peter Kamolz ; Judith Holzer
Delivery of antiseptic solutions by a bacterial cellulose wound dressing: Uptake, release and antibacterial efficacy of octenidine and povidone-iodine
Coremed, Health
2020

Delivery of antiseptic solutions by a bacterial cellulose wound dressing: Uptake, release and antibacterial efficacy of octenidine and povidone-iodine

Authors Ives Bernardelli de Mattos; Sebastian P Nischwitz ; Alexandru-Cristian Tuca; Florian Groeber-Becker; Martin Funk; Thomas Birngruber ; Selma Mautner ; Lars-Peter Kamolz ; Judith Holzer
Delivery of antiseptic solutions by a bacterial cellulose wound dressing: Uptake, release and antibacterial efficacy of octenidine and povidone-iodine
Health
2019

Topical application of haemoglobin: a safety study

Authors Holzer, Judith CJ; Birngruber, Thomas; Mautner, Selma; Graff, Alexander; Kamolz, Lars-Peter
Topical application of haemoglobin: a safety study
Health
2019

Uptake of PHMB in a bacterial nanocellulose-based wound dressing: A feasible clinical procedure

Authors de Mattos, Ives Bernardelli; Holzer, Judith C.J.; Tuca, Alexandru-Cristian; Groeber-Becker, Florian; Funk, Martin; Popp, Daniel; Mautner, Selma; Birngruber, Thomas; Kamolz, Lars-Peter
Uptake of PHMB in a bacterial nanocellulose-based wound dressing: A feasible clinical procedure
Health
2019

Comparison of cerebral Open Flow Microperfusion and Microdialysis when sampling small lipophilic and small hydrophilic substances

Authors Altendorfer-Kroath, Thomas; Schimek, Denise; Eberl, Anita; Rauter, Günther; Ratzer, Maria; Raml, Reingard; Sinner, Frank; Birngruber, Thomas
Comparison of cerebral Open Flow Microperfusion and Microdialysis when sampling small lipophilic and small hydrophilic substances
Health
2019

LC/MS/MS analyses of open-flow microperfusion samples quantify eicosanoids in a rat model of skin inflammation

Authors Pipper, Cornelia; Bordag, Natalie; Reiter, Bernadette; Economides, Kyriakos; Florian, Peter; Birngruber, Thomas; Sinner, Frank; Bodenlenz, Manfred; Eberl, Anita
LC/MS/MS analyses of open-flow microperfusion samples quantify eicosanoids in a rat model of skin inflammation
Health
2019

Insulin distribution in human adipose tissue via a novel insulin infusion catheter

Authors Altendorfer‐Kroath, Thomas; Schwingenschuh, Simon; Schondorff-Kruse, Pernelle; Heschel, Matthias; Sinner, Frank; Birngruber, Thomas
Insulin distribution in human adipose tissue via a novel insulin infusion catheter
Health
2019

Extracellular Vesicles in Human Skin: Cross-Talk from Senescent Fibroblasts to Keratinocytes by miRNAs

Authors Terlecki-Zaniewicz, Lucia; Pils, Vera; Bobbili, Madhusudhan Reddy; Lämmermann, Ingo; Perrotta, Ida; Grillenberger, Tonja; Schwestka, Jennifer; Weiß, Katrin; Pum, Dietmar; Arcalis, Elsa; Schwingenschuh, Simon; Birngruber, Thomas; Brandstetter, Marlene; Heuser, Thomas; Schosserer, Markus; Morizot, Frederique; Mildner, Michael; Stöger, Eva; Tschachler, Erwin; Weinmüllner, Regina; Gruber, Florian; Grillari, Johannes
Extracellular Vesicles in Human Skin: Cross-Talk from Senescent Fibroblasts to Keratinocytes by miRNAs
Health
2019

Cerebral Open Flow Microperfusion to Monitor Drug Transport Across the Blood‐Brain Barrier

Authors Hummer, Joanna; Altendorfer‐Kroath, Thomas; Birngruber, Thomas
Cerebral Open Flow Microperfusion to Monitor Drug Transport Across the Blood‐Brain Barrier
Coremed, Health
2019

Topical application of haemoglobin: a safety study

Authors Judith Holzer ; Thomas Birngruber ; Selma Mautner ; Alexander Graff (Technical Department; Austrian Dust-Silicosis Control Center (ÖSBS)); Lars-Peter Kamolz
Topical application of haemoglobin: a safety study
Coremed, Health
2019

Delivery of antiseptic solutions by a bacterial cellulose wound dressing: Uptake, release and antibacterial efficacy of octenidine and povidone-iodine

Authors Ives Bernardelli de Mattos; Sebastian P Nischwitz ; Alexandru-Cristian Tuca; Florian Groeber-Becker; Martin Funk; Thomas Birngruber ; Selma Mautner ; Lars-Peter Kamolz ; Judith Holzer
Delivery of antiseptic solutions by a bacterial cellulose wound dressing: Uptake, release and antibacterial efficacy of octenidine and povidone-iodine
Health
2018

Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood–brain barrier in leptin resistant mice

Authors Kleinert, Maximilian; Kotzbeck, Petra; Altendorfer‐Kroath, Thomas; Birngruber, Thomas; Tschöp, Matthias H.; Clemmensen, Christoffer
Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood–brain barrier in leptin resistant mice
Health
2018

Filamentous Aggregation of Sequestosome-1/p62 in Brain Neurons and Neuroepithelial Cells upon Tyr-Cre-Mediated Deletion of the Autophagy Gene Atg7

Authors Sukseree, Supawadee; László, Lajos; Gruber, Florian; Bergmann, Sophie; Narzt, Marie Sophie; Nagelreiter, Ionela Mariana; Höftberger, Romana; Molnár, Kinga; Rauter, Günther; Birngruber, Thomas; Larue, Lionel; Kovacs, Gabor G.; Tschachler, Erwin; Eckhart, Leopold
Filamentous Aggregation of Sequestosome-1/p62 in Brain Neurons and Neuroepithelial Cells upon Tyr-Cre-Mediated Deletion of the Autophagy Gene Atg7
Coremed, Health
2018

Uptake of PHMB in a bacterial nanocellulose-based wound dressing: A feasible clinical procedure

Authors Ives Bernardelli de Mattos; Judith Holzer ; Alexandru-Cristian Tuca; Florian Groeber-Becker; Martin Funk; Daniel Popp; Selma Mautner ; Thomas Birngruber ; Lars Kamolz
Uptake of PHMB in a bacterial nanocellulose-based wound dressing: A feasible clinical procedure
Coremed, Health
2018

Granulox: Eine Safety Studie

Authors Judith Holzer ; Thomas Birngruber ; Selma Mautner ; Lars-Peter Kamolz
Granulox: Eine Safety Studie
Coremed, Health
2018

Einfluss von sekundären Wundauflagen auf die Wirkung von Epicite Hydro: Ergebnisse einer Tierexperimentellen Studie

Authors Tuca; A. C.; Funk; M.; Palackic; A.; Bernardelli de Mattos; I.; Groeber-Becker; F.; Judith Holzer ; Thomas Birngruber ; Lars-Peter Kamolz
Einfluss von sekundären Wundauflagen auf die Wirkung von Epicite Hydro: Ergebnisse einer Tierexperimentellen Studie
Coremed, Health
2018

Die Aufnahme von PHMB in epicite: eine Studie zur klinischen Anwendbarkeit

Authors Judith Holzer ; A. Tuca; I. Bernardelli de Mattos; F. Groeber-Becker; M. Funk; D. Popp; Selma Mautner ; Thomas Birngruber ; Lars-Peter Kamolz
Die Aufnahme von PHMB in epicite: eine Studie zur klinischen Anwendbarkeit
Health
2017

Chronic intrahypothalamic rather than subcutaneous liraglutide treatment reduces body weight gain and stimulates the melanocortin receptor system.

Authors Kaineder, K; Birngruber, Thomas; Rauter, G; Obermüller, B; Eichler, J; Münzker, J; Al-Zoughbi, W; Mautner, S I; Torekov, S S; Hartmann, B; Others; Kotzbeck, P; Pieber, Thomas R
Chronic intrahypothalamic rather than subcutaneous liraglutide treatment reduces body weight gain and stimulates the melanocortin receptor system.
Health
2017

Quantification of Basal Insulin Peglispro and Human Insulin in Adipose Tissue Interstitial Fluid by Open-Flow Microperfusion

Authors Tiffner, Katrin Irene; Boulgaropoulos, Beate; Höfferer, Christian; Birngruber, Thomas; Porksen, Niels; Linnebjerg, Helle; Garhyan, Parag; Lam, Eric Chen Quin; Knadler, Mary Pat; Pieber, Thomas R; Sinner, Frank M.
Quantification of Basal Insulin Peglispro and Human Insulin in Adipose Tissue Interstitial Fluid by Open-Flow Microperfusion
Health
2017

Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence

Authors Bodenlenz, Manfred; Tiffner, Katrin Irene; Raml, Reingard; Augustin, Thomas; Dragatin, Christian; Birngruber, Thomas; Schimek, Denise; Schwagerle, Gerd; Pieber, Thomas R.; Raney, Sam G.; Kanfer, Isadore; Sinner, Frank
Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence
Health
2016

Determination of (2)H-enrichment of rat brain interstitial fluid and rat plasma by headspace-gas-chromatography - quadrupole-mass-spectrometry

Authors Eberl, A; Altendorfer‐Kroath, Thomas; Kollmann, D; Birngruber, Thomas; Sinner, F; Raml, R; Magnes, Christoph
Determination of (2)H-enrichment of rat brain interstitial fluid and rat plasma by headspace-gas-chromatography - quadrupole-mass-spectrometry
Health
2016

Cerebral open flow microperfusion (cOFM) an innovative interface to brain tissue

Authors Birngruber, Thomas; Sinner, Frank
Cerebral open flow microperfusion (cOFM) an innovative interface to brain tissue
Health
2014

Assessment of blood-brain barrier function and the neuroinflammatory response in the rat brain by using cerebral open flow microperfusion (cOFM).

Authors Ghosh, Arijit; Birngruber, Thomas; Sattler, Wolfgang; Kroath, Thomas; Ratzer, Maria; Sinner, Frank M.; Pieber, Thomas R
Assessment of blood-brain barrier function and the neuroinflammatory response in the rat brain by using cerebral open flow microperfusion (cOFM).
Health
2014

Long-Term Implanted cOFM Probe Causes Minimal Tissue Reaction in the Brain

Authors Birngruber, Thomas; Ghosh, Arijit; Hochmeister, Sonja; Asslaber, Martin; Kroath, Thomas; Pieber, Thomas R.; Sinner, Frank
Long-Term Implanted cOFM Probe Causes Minimal Tissue Reaction in the Brain
Health
2013

Clinical applicability of dOFM devices for dermal sampling.

Authors Bodenlenz, Manfred; Aigner, B; Dragatin, C; Liebenberger, L; Zahiragic, S; Höfferer, C; Birngruber, Thomas; Priedl, J; Feichtner, F; Schaupp, L; Korsatko, S; Ratzer, M; Magnes, Christoph; Pieber, Thomas R; Sinner, F
Clinical applicability of dOFM devices for dermal sampling.
Health
2013

Enhanced absorption of insulin aspart as the result of a dispersed injection strategy tested in a randomized trial in type 1 diabetic patients

Authors Mader, Julia K; Birngruber, Thomas; Korsatko, Stefan; Deller, Sigrid; Köhler, Gerd; Boysen, Susanne; Augustin, Thomas; Mautner, Selma; Sinner, Frank; Pieber, Thomas R; AP@home Consortium
Enhanced absorption of insulin aspart as the result of a dispersed injection strategy tested in a randomized trial in type 1 diabetic patients
Health
2013

Cerebral open flow microperfusion: a new in vivo technique for continuous measurement of substance transport across the intact blood-brain barrier.

Authors Birngruber, Thomas; Ghosh, Arijit; Perez-Yarza, Veronica; Kroath, Thomas; Ratzer, Maria; Pieber, Thomas R; Sinner, Frank M.
Cerebral open flow microperfusion: a new in vivo technique for continuous measurement of substance transport across the intact blood-brain barrier.
Health
2012

Open Flow Microperfusion: An Alternative Method to Microdialysis?

Authors Pieber, Thomas R; Birngruber, Thomas; Bodenlenz, Manfred; Höfferer, Christian; Mautner, S. I.; Tiffner, Katrin Irene; Sinner, Frank M.
Open Flow Microperfusion: An Alternative Method to Microdialysis?
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