Unique de-risking and proof-of-mechanism studies for dermal active ingredients
Ex-Vivo Studies
The kinetics of topical drugs are investigated using fresh/frozen tissue from animals and human donors. The data are important to support preclinical drug development regarding lead selection, formulation screening, and optimization.
In-Vivo Studies
We conduct studies to investigate the permeation, stability, and pharmacokinetics/pharmacodynamics (PK/PD) of a topical active pharmaceutical ingredient under development.
OFM studies in live animals with active blood and lymph circulation provide important information such as the distinction between permeation and clearance kinetics. The unique capability of OFM technology enables the study of large molecular compounds and immune cells for a better understanding of the mechanism of action (MOA) of the drug candidate under investigation. As a result, the in-vivo OFM approach has proven its value in predicting clinical efficacy and supports the right development decisions before entering the clinical phase.
Fast and efficient PK-based bioequivalence studies for topical generics
Specialized methods for analyses and testing for preclincial and clinical studies (GLP and non-GLP).
Instruments and methods for the measurement of pharmacokinetics and pharmacodynamics in different tissues.
Comprehensive and compliant data management and biostatistics for clinical trials
We test drug release in a fast and reliable way using IVRT based on vertical diffusion cells and synthetic membranes.
We perform untargeted and targeted metabolomics studies to quantify metabolites to investigate metabolic processes and identify biomarkers.
The digital checklist and cross-professional process documentation for surgical procedures.
CDS-BARS module for patient-centered, cross-professional, interdisciplinary collaboration and documentation on acute geriatric wards
We offer extensive, professional support in reporting and publishing the results of your preclinical and clinical studies.
aOFM can be used to monitor local drug distribution and biomarkers in subcutaneous adipose tissue.
Die JOANNEUM RESEARCH ist Innovations- und Technologieanbieter im Bereich der angewandten Forschung. Als Forschungsgesellschaft der Länder und Regionen prägen wir mit unseren Forschungskompetenzen die Entwicklung unserer modernen Gesellschaft und Wirtschaft nachhaltig und menschenzentriert. Als multidisziplinäres Team in flexiblen, innovationsfreundlichen Strukturen leben wir höchste gesellschaftliche und wissenschaftliche Ansprüche.